eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2020
vol. 16
 
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Obstetrics and gynaecology
abstract:
State of the art paper

Perinatal transmission of hepatitis C virus: an update

Mortada H.F. El-Shabrawi
1
,
Naglaa M. Kamal
1
,
Engy A. Mogahed
1
,
Mona A. Elhusseini
2
,
Mohamed F. Aljabri
3

1.
Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Egypt
2.
Department of Obstetrics and Gynecology, Red Crescent Hospital, Cairo, Egypt
3.
Department of Pediatrics and Pediatric Neurology, Alhada Armed Forces Hospital, Taif, Saudi Arabia
Arch Med Sci 2020; 16 (6): 1360–1369
Online publish date: 2019/03/15
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Infection with hepatitis C virus (HCV) is a major health problem worldwide. A large proportion of perinatal HCV infections are silent and may present later in adulthood with long-term complications. HCV has no effective immune prophylaxis and hence appropriate follow-up of all infants born to HCV-infected mothers is necessary. Universal antenatal screening for HCV is largely debatable. Intrauterine and partum transmission of HCV are both possible and higher rates are associated with a high maternal serum viral load (> 106 copies per milliliter), concomitant HIV infection, prolonged or difficult delivery, and invasive fetal monitoring during delivery. Infection during pregnancy and infancy needs to be investigated more in order to design management strategies for perinatal transmission of HCV most effectively. The recently approved new-generation, oral, direct-acting antiviral drugs may open a new era in HCV therapy for pregnant women and infected infants if proved to be safe during conception and infancy.
keywords:

hepatitis C virus, perinatal transmission, vertical transmission, children, direct-acting antiviral drugs

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