eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank

 
3/2021
vol. 53
 
Share:
Share:
more
 
 
abstract:
Original paper

Perioperative presepsin as a potential early predictor for postoperative infectious complications in cardiac surgery

Hiroto Suzuki
1
,
Hiroto Narimatsu
2
,
Masaki Nakane
3
,
Mitsuaki Sadahiro
4
,
Kaneyuki Kawamae
1

1.
Department of Anaesthesiology, Yamagata University Faculty of Medicine, Yamagata, Japan
2.
Cancer Prevention and Cancer Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
3.
Department of Emergency and Critical Care Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
4.
Department of Cardiovascular, Thoracic and Pediatric Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan
Anaesthesiol Intensive Ther 2021; 53, 3: 215–222
Online publish date: 2021/08/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Postoperative infection remains a serious complication of cardiac surgery; however, no existing biomarkers can detect infection in the early perioperative period. We investigated the usefulness of presepsin, a novel biomarker, in predicting postoperative infectious complications in cardiac surgery with cardiopulmonary bypass.

Material and methods
For patients aged > 18 years who underwent elective cardiac surgery with cardiopulmonary bypass between 2015 and 2017, data of clinical features, perioperative presepsin levels, and infectious complications were collected. We compared the perioperative presepsin levels between the infected and non-infected groups, performed a risk factor analysis for postoperative infection, and calculated the cut-off value of presepsin with postoperative infection.

Results
Among the 73 included patients, 20 developed postoperative infectious complications. The presepsin levels pre-operatively and on post-operative day (POD) zero were significantly higher in the infected than in the non-infected group (145.2 vs. 93.2, 514.0 vs. 328.1 [pg mL-1], p < 0.05, respectively). The odds ratio (OR) for postoperative infection included pre-operative presepsin (OR; 1.22 [confidence interval; 1.07–1.40]/10 pg mL-1) and presepsin on POD zero (OR; 1.31 [confidence interval; 1.05–1.64] /100 pg mL-1). The cut-off predictive values for postoperative infectious complications of pre-operative presepsin and on POD zero were 132 and 347 [pg mL-1], respectively.

Conclusions
Perioperative presepsin levels could be an early predictor for postoperative infectious complications in cardiac surgery.

keywords:

cardiac surgery, presepsin, postoperative infection, soluble CD14 subtype, predictable marker

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe