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ISSN: 0034-6233
Reumatologia/Rheumatology
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4/2016
vol. 54
 
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abstract:
Review paper

Personalized medicine in rheumatology

Anna Kłak, Agnieszka Paradowska-Gorycka, Brygida Kwiatkowska, Filip Raciborski

Reumatologia 2016; 54, 4: 177–186
Online publish date: 2016/10/05
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In the era of the 21st century, rheumatoid arthritis (RA) is still poorly characterized. Rheumatoid

arthritis is a common but heterogeneous disease, not only in the course and clinical symptoms, but also in the clinical response to treatment. Now it is known that early, correct diagnosis and starting treatment with disease-modifying drugs (DMARDs), of which methotrexate (MTX) remains the gold standard in the treatment of RA, is crucial in order to prevent joint destruction, functional disability and an unfavourable disease outcome. Early diagnosis of rheumatoid arthritis is significant in so much as the primary treatment can be started better. Pharmacogenetic and pharmacogenomic studies, which help determine the genetic profile of individual patients, may bring us closer to personalized medicine. Further studies on RA should allow for the identification of disease-specific genes at the stage when their tolerance by the organism is still preserved (before auto-aggression develops).
keywords:

personalized medicine, rheumatoid arthritis, biomarkers, genetic test

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