eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 48
Experimental immunology

Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer

Xiaobo Wang
Lei Ren
2, 3
Linhan Ye
Jing Cao

Department of General Surgery, the Second Xiangya Hospital of Central South University
Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Germany
Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Germany
Department of General Surgery, Xiangya Hospital of Central South University, China
Cent Eur J Immunol 2023; 48 (3): 189-202
Online publish date: 2023/09/29
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Colorectal cancer is one of the most frequently diagnosed cancers. Immunotherapy has been proven to be a potential treatment option for colorectal cancer. Colorectal cancer maintains immune escape by expressing low immunogenicity and following the tolerogenic cell death pathway. There is also emerging evidence that oxaliplatin and photodynamic therapy (PDT) can promote anti-tumor immunity. However, the effect of PDT combined with oxaliplatin on colorectal cancer remains elusive. Here, we analyzed the viability of HCT116 and DLD-1 cell lines after treatment with the combination of PDT and oxaliplatin. We found that the viability decreased significantly after the combination treatment. Meanwhile, we also detected that sinoporphyrin sodium (DVDMS)-derived PDT could amplify oxaliplatin-induced immunogenic cell death (ICD) in different colorectal cancer cell lines. More importantly, the combination of DVDMS-derived PDT and oxaliplatin presented strong immunogenic potential in immunocompetent BALB/c mice in the vaccination assay. Taken together, our data demonstrated that the combination of DVDMS-derived PDT and oxaliplatin is a potential novel therapy for colorectal cancer.

autophagy, colorectal cancer, oxaliplatin, photodynamic therapy, immunogenic cell death

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