Full text
3/2026
vol. 113
Review article
Platelet-Rich Plasma in Wound Treatment
Students’ Scientific Club of Dermatology, Department of Dermatology and Venereology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Department of Dermatology and Venereology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Dermatol Rev/Przegl Dermatol 2026, 113, 151–157
Data publikacji online: 2026/09/09
Article file
- Piszczorowicz Ł., Król D., Dyląg S.: Autologous platelet-rich plasma therapy – a promising method for tissue repair/regeneration in many medical fields. J Transf Med Hemostasis 2020, 13, 135-148.
- Tysiąc-Miśta M., Gruca O., Bulanda S., Trzeciak H., Wyszyńska M., Kasperski J.: The use of platelet-rich plasma in medicine with particular reference to dentistry and aesthetic medicine. Prosthodontics 2019, 69, 270-281.
- Eming S.A., Martin P., Tomic-Canic M.: Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med 2014, 6, 265sr6.
- Frykberg R.G., Banks J.: Challenges in the treatment of chronic wounds. Adv Wound Care 2015, 4, 560-582.
- Merchán W.H., Gómez L.A., Chasoy M.E., Alfonso-Rodríguez C.A., Muńoz A.L.: Platelet-rich plasma, a powerful tool in dermatology. J Tissue Eng Regen Med 2019, 13, 892-901.
- Everts P., Onishi K., Jayaram P., Lana J.F., Mautner K.: Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci 2020, 21, 7794.
- Martin R.F.: Wound healing. Surg Clin North Am 2020, 100, ix-xi. Doi:10.1016/j.suc.2020.05.012.
- Al-Gharibi K.A., Sharstha S., Al-Faras M.A.: Cost-effectiveness of wound care: a concept analysis. Sultan Qaboos Univ Med J 2018, 18, e433-e439.
- Alves R., Grimalt R.: A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord 2018, 4, 18-24.
- Bakshi N., Khan M., Bedi A.: Growth factors. In: Biologics in Orthopaedic Surgery. A.D. Mazzocca, A.D. Lindsay (eds.). Elsevier 2019, 19-25.
- Pixley J.N., Cook M.K., Singh R., Larrondo J., McMichael A.J.: A comprehensive review of platelet-rich plasma for the treatment of dermatologic disorders. J Dermatolog Treat 2023, 34, 2142035.
- Mazzocca A.D., Lindsay A.D.: Index. In: Biologics in Orthopaedic Surgery. A.D. Mazzocca, A.D. Lindsay (eds.). Elsevier 2019, 215-221.
- Liu Y., Chen N.: Clinical evaluation of continuous irrigation with Bikerui combined with negative pressure closed drainage and platelet-rich plasma technique for treatment of stage III-IV pressure ulcer. Adv Dermatol Alergol 2024, 41, 181-188.
- Sharma A.K., Kaur A., Asthana S.S., Nongrum I.P., Rai S., Sunaina K.: Role of autologous platelet-rich fibrin in chronic non-healing ulcers with various etiologies in a tertiary care rehabilitation centre: a case series. Cureus 2024, 16, e68709.
- Singh G., Borah D., Khanna G., Jain S.: Efficacy of local autologous platelet-rich plasma in the treatment of pressure ulcer in spinal cord injury patients. Cureus 2021, 13, e18668.
- Singh R., Rohilla R.K., Dhayal R.K., Sen R., Sehgal P.K.: Role of local application of autologous platelet-rich plasma in the management of pressure ulcers in spinal cord injury patients. Spinal Cord 2014, 52, 809-816.
- Su R., Sun L., Ding Y.F., Pan Z., Yang F.Y., Fang H., et al.: In vitro studies on the effects of cryopreserved platelet-rich plasma on cells related to wound healing. Platelets 2024, 35, 2347331.
- Liu Q., Zhang N., Li Z., He H.: Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life. Clinics 2021, 76, e2355.
- Jeschke M.G., van Baar M.E., Choudhry M.A., Chung K.K., Gibran N.S., Logsetty S.: Burn injury. Nat Rev Dis Primers 2020, 6, 11.
- Hall C., Hardin C., Corkins C.J., Jiwani A.Z., Fletcher J., Carlsson A., et al.: Pathophysiologic mechanisms and current treatments for cutaneous sequelae of burn wounds. Compr Physiol 2017, 8, 371-405.
- Marck R.E., Gardien K.L., Stekelenburg C.M., Vehmeijer M., Baas D., Tuinebreijer W.E., et al.: The application of platelet- rich plasma in the treatment of deep dermal burns: a randomized, double-blind, intra-patient controlled study. Wound Repair Regen 2016, 24, 712-720.
- Korzon-Burakowska A.: Zespół stopy cukrzycowej – patogeneza i praktyczne aspekty postępowania. Choroby Serca Naczyń 2007, 4, 93-98.
- Sun H., Saeedi P., Karuranga S., Pinkepank M., Ogurtsova K., Duncan B.B., et al.: IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 2022, 183, 109119.
- Lerman O.Z., Galiano R.D., Armour M., Levine J.P., Gurtner G.C.: Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 2003, 162, 303-312.
- Spravchikov N., Sizyakov G., Gartsbein M., Accili D., Tennenbaum T., Wertheimer E.: Glucose effects on skin keratinocytes: implications for diabetes skin complications. Diabetes 2001, 50, 1627-1635.
- Sawaya A.P., Stone R.C., Brooks S.R., Pastar I., Jozic I., Hasneen K., et al.: Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nat Commun 2020, 11, 4678.
- Alvarsson A., Sandgren B., Wendel C., Alvarsson M., Brismar K.: A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented? Cardiovasc Diabetol 2012, 11, 18.
- Kunder V., Sharma K.C., Rizvi Z., Soubelet R., Ducharme M.: The use of platelet-rich plasma in the treatment of diabetic foot ulcers: a scoping review. Cureus 2023, 15, e43452.
- Malekpour Alamdari N., Shafiee A., Mirmohseni A., Besharat S.: Evaluation of the efficacy of platelet-rich plasma on healing of clean diabetic foot ulcers: a randomized clinical trial in Tehran, Iran. Diabetes Metab Syndr 2021, 15, 621-626.
- Li W., Wang Q.Y., Bai X.G., Xu J.: Autologous platelet-rich gel in the treatment of diabetic foot ulcers: a retrospective study. Medicine 2022, 101, e31701.
- Weller C., Evans S.: Venous leg ulcer management in general practice--practice nurses and evidence based guidelines. Aust Fam Physician 2012, 41, 331-337.
- O’Meara S., Cullum N., Nelson E.A., Dumville J.C.: Compression for venous leg ulcers. Cochrane Database Syst Rev 2012, 11, CD000265.
- Miłek T., Nagraba Ł., Mitek T., Woźniak W., Mlosek K., Olszewski W., et al.: Autologous platelet-rich plasma reduces healing time of chronic venous leg ulcers: a prospective observational study. Adv Exp Med Biol 2019, 1176, 109-117.
- Sampson S., Gerhardt M., Mandelbaum B.: Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med 2008, 1, 165-174.
- Hom D.B., Linzie B.M., Huang T.C.: The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007, 9, 174-183.
- Marlovits S., Mousavi M., Gäbler C., Erdös J., Vécsei V.: A new simplified technique for producing platelet-rich plasma: a short technical note. Eur Spine J 2004, 13 Suppl 1, S102-S106.
- Morimoto N., Kakudo N., Matsui M., Ogura T., Hara T., Suzuki K., et al.: Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. BMJ Open 2015, 5, e007733.
Copyright: © 2026 Polish Dermatological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

