Studia Medyczne

Abstract

4/2019 vol. 35
Original paper

Oxidative stress markers are increased in non-alcoholic fatty liver disease patients with high serum alanine aminotransferase levels

Suzan Muratoglu Severcan 1
,
Ayse Bilgihan 2
,
Gulbanu Erkan 3
,
Ugur Ercin 2
,
Cinar Severcan 4
  1. Department of Medical Biochemistry, Institute of Health Sciences, Gazi University, Ankara, Turkey
  2. Department of Medical Biochemistry, Medical Faculty, Ufuk University, Ankara, Turkey
  3. Division of Gastroenterology, Department of Internal Medicine, Istanbul Medipol University, Istanbul, Turkey
  4. Department of Biochemistry, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, Zonguldak, Turkey
Medical Studies/Studia Medyczne 2019; 35 (4): 283–287
DOI: https://doi.org/10.5114/ms.2019.91245
Online publish date: 2019/12/30
View full text
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease

Introduction

Non-alcoholic fatty liver disease (NAFLD) is a pathological disease that causes chronic damage in the liver without alcohol consumption.

Aim of the research

To determine oxidative stress and inflammation statuses (NAFLD) with increased alanine aminotransferase (ALT).

Material and methods

Oxidative stress (malondialdehyde (MDA), advanced oxidation protein products (AOPP), inflammation (serum tumour necrosis factor-α (TNF-α)), interleukin-6 (IL-6), and hyaluronic acid (HA) were measured by the ELISA method or manually. A total of 133 non-obese and non-diabetic individuals were included. Patients diagnosed with NAFLD with normal ALT levels were included in group 1 (n = 53), and those with high ALT levels were included in group 2 (n = 35). The control group included individuals without any known systemic disease (n = 45).

Results

We found that the serum MDA levels were significantly elevated in group 2 in comparison to the control group (p < 0.05). However, there were no significant changes in the serum AOPP levels in any group (p > 0.05). The serum TNF-α and IL-6 levels of group 1 and group 2 were higher than those in the control group (p < 0.05). The serum HA levels in group 2 increased significantly in comparison to the other groups (p < 0.05).

Conclusions

HA and MDA were enhanced with high ALT levels and with elevated TNF-α and IL-6 levels without high ALT levels in NAFLD.

>

Keywords

inflammation, oxidative stress, alanine aminotransferase, non-alcoholic fatty liver disease

Share
without publication fees
Coverage in
Integrated with
plagiat pl
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications