Abstract
Position of omalizumab therapy in the treatment of spontaneous chronic urticaria. A case series and literature review
- Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland
Katedra i Klinika Dermatologii, Uniwersytet Jagielloñski Collegium Medicum, Kraków, Polska
Introduction
Urticaria is an etiopathologically complex disease. Current guidelines recommend an algorithm for urticaria treatment, which includes omalizumab as third line treatment.
Objective
To evaluate clinical efficacy of omalizumab in patients with urticaria.
Case report
Three women were treated with omalizumab for spontaneous chronic urticaria, resistant to standard therapy patterns. The concentration of total IgE determined in patients during omalizumab therapy in the first case was originally maintained at a low level, while during the continuation of the treatment it increased four times. In the second case, originally a near 2-fold decrease of total IgE concentration was observed, then it increased 1.5 times.
Conclusions
The obtained data confirm a high efficacy of omalizumab therapy in patients with spontaneous chronic urticaria. Fast and complete or nearly complete resolution of urticaria symptoms was observed during the treatment.
Keywords
treatment, urticaria, omalizumab
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