eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank

 
2/2020
vol. 26
 
Share:
Share:
more
 
 
abstract:
Review paper

Possible association between haemostasis dysfunction and early onset of microvascular complications in patients with type 1 diabetes

Jarmila Vojtková
1
,
Katarína Motyková
1
,
Peter Bánovčin
1

1.
Department of Pediatrics, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovak Republic
Pediatr Endocrinol Diabetes Metab 2020; 26 (2): 89–96
Online publish date: 2020/06/22
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Chronic hyperglycaemia, the effect of which is enhanced with diabetes duration and poor compensation, has a great impact on the complex aetiopathogenesis of microvascular diabetic complications. However, other factors are particularly likely in young patients with early onset of chronic complications. One of the possible risk factors is procoagulant condition, which can lead to small vessel microthromboses, endothelial damage, and ultimately specific organ manifestations. While these changes are well described in a group of adult patients with type 2 diabetes, similar information is less in the population of children and adults with type 1 diabetes (T1D). Changes in haemostasis may be associated with hyperglycaemia and subclinical inflammation or specific gene polymorphisms. Alternatively, they can occur due to coincidence with inherited thrombophilic disorders or sticky platelet syndrome. Finally, T1D is an autoimmune disease that can be associated with other autoimmune conditions, e.g. lupus anticoagulant. From the clinical point of view, mainly cases with early onset of chronic diabetic complications that cannot be explained by long duration or insufficient compensation of diabetes might be suspicious from the procoagulant changes and their screening might be discussed.
keywords:

antiphospholipid antibodies, type 1 diabetes, microvascular complications, haemostasis dysfunction, inherited thrombophilic disorders

Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe