Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma

Ozgur Surmelioglu; Kıvılcım Erdogan; Muhammed Dagkiran; Suleyman Ozdemir; Ozgur Tarkan; Aysun Uguz

doi:10.5114/pjp.2022.117177

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Original paper

Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma

Ozgur Surmelioglu

¹

,

Kıvılcım Eren Erdogan

²

,

Muhammed Dagkiran

¹

,

Suleyman Ozdemir

¹

,

Ozgur Tarkan

¹

,

Aysun Uguz

²

Department of Otorhinolaryngology, Faculty of Medicine, Cukurova University, Adana, Turkey

Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey

Pol J Pathol 2022; 74 (1): 43-49

DOI: https://doi.org/10.5114/pjp.2022.117177

Online publish date: 2022/06/29

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AMA

Surmelioglu O, Erdogan KE, Dagkiran M, Ozdemir S, Tarkan O, Uguz A. Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma. Polish Journal of Pathology. 2022;73(1):43-49. doi:10.5114/pjp.2022.117177.

APA

Surmelioglu, O., Erdogan, K. E., Dagkiran, M., Ozdemir, S., Tarkan, O.,  & Uguz, A. (2022). Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma. Polish Journal of Pathology, 73(1), 43-49. https://doi.org/10.5114/pjp.2022.117177

Chicago

Surmelioglu, Ozgur, Kıvılcım E Erdogan, Muhammed Dagkiran, Suleyman Ozdemir, Ozgur Tarkan,  and Aysun Uguz. 2022. "Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma". Polish Journal of Pathology 73 (1): 43-49. doi:10.5114/pjp.2022.117177.

Harvard

Surmelioglu, O., Erdogan, K., Dagkiran, M., Ozdemir, S., Tarkan, O.,  and Uguz, A. (2022). Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma. Polish Journal of Pathology, 73(1), pp.43-49. https://doi.org/10.5114/pjp.2022.117177

MLA

Surmelioglu, Ozgur et al. "Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma." Polish Journal of Pathology, vol. 73, no. 1, 2022, pp. 43-49. doi:10.5114/pjp.2022.117177.

Vancouver

Surmelioglu O, Erdogan K, Dagkiran M, Ozdemir S, Tarkan O, Uguz A. Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma. Polish Journal of Pathology. 2022;73(1):43-49. doi:10.5114/pjp.2022.117177.

PlumX metrics:

To evaluate the predictive value of CD44 and aldehyde dehydrogenase 1 (ALDH1) expression for prognosis and radiotherapy (RT) response in patients with early-stage laryngeal cancer receiving RT.

Forty-four patients with early-stage laryngeal cancer diagnosed between 2002 and 2016 were included in the study. The correlation between RT response and pre-treatment immunohistochemical ALDH1 and CD44 staining was evaluated. In addition, survival times were compared between groups.

The mean age of the 44 patients was 59.8 ±9.0 (43-81) years and 41 were male. There were 20 patients in the non-recurrent group (all men) and 24 patients in the recurrent group (21 men). Immunohistochemical positivity for ALDH1 was found to be a significant risk factor for RT failure (p = 0.0001), whereas CD44 positivity (p = 0.114) and age group (p = 0.287) were not significant.

ALDH1 positivity was identified as a significant predictor of DFS and RT sensitivity, while CD44 positivity did not differ according to RT response.

keywords:

Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma

Ozgur Surmelioglu 1 , Kıvılcım Eren Erdogan 2 , Muhammed Dagkiran 1 , Suleyman Ozdemir 1 , Ozgur Tarkan 1 , Aysun Uguz 2

laryngeal squamous cell carcinoma, ALDH1, CD44, radiotherapy

Ozgur Surmelioglu

¹

,

Kıvılcım Eren Erdogan

²

,

Muhammed Dagkiran

¹

,

Suleyman Ozdemir

¹

,

Ozgur Tarkan

¹

,

Aysun Uguz

²