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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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6/2010
vol. 48
 
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abstract:
Review paper

Primary Sjögren’s syndrome or manifestations of hepatitis C virus infection?

Irena Zimmermann-Górska

Reumatologia 2010; 48, 6: 442–445
Online publish date: 2010/12/20
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Chronic hepatitis C virus (HCV) infection in now relatively common. Moreover, frequent associations with HCV infections and connective tissue diseases (CTD), including Sjögren’s syndrome (SS), are observed. It is critical to know if HCV predisposes to or causes CTD or the reported association results from the chance alone. HCV infection and SS manifest with many common symptoms and serological abnormalities. HCV – associated SS is indistinguishable in most cases of the primary syndrome when using 2002 classification criteria. At the same time, HCV infection is one of the exclusions of SS in these criteria. It is controversial. New terms like “SS associated with HCV” or “SS secondary to HCV” are proposed when patients with HCV infection fulfill criteria for SS. The main differences between primary and HCV-related SS are anti-Ro/SS-A and anti-La/SS-B antibodies which are much more frequently detected in the primary form.
keywords:

Sjögren’s syndrome, HCV infection




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