eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2021
vol. 72
 
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abstract:
Original paper

Prognostic and predictive value of EZH2 expression and the tumor immune microenvironment in Merkel cell carcinoma

Arbil Acikalin
1
,
Emine Bagir
1
,
Semra Paydas
2

1.
Pathology Department, Medical Faculty, Cukurova University, Adana, Turkey
2.
Oncology Department, Medical Faculty, Cukurova University, Adana, Turkey
Pol J Pathol 2021; 72 (2): 140-147
Online publish date: 2021/09/30
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Merkel cell carcinoma (MCC) is a rare and lethal type of skin cancer characterized by frequent recurrences and metastases. In view of the lack of a proven treatment option for MCC, we immunochemically evaluated the presence of Merkel cell polyomavirus (MCPyV), PD-1, PD-L1, CD8, and EZH2 on slides prepared from tumor tissues of 13 patients with MCC, and examined their association with disease progression and overall survival. PD-1 was expressed on tumor infiltrating lymphocytes (TILs) in 92.3% of the patients. None of the tumor cells expressed PD-L1. CD8 levels were higher in MCPyV-positive tumors. Interestingly, higher CD8 levels correlated with better overall survival (p = 0.025), while higher EZH2 expression correlated with metastasis/recurrence (z = –1.396, p = 0.089). However, low EZH2 expression was associated with poor overall survival (χ2 = 3.745, Cramer V = 0.537, p = 0.086). These findings suggest that EZH2 plays a significant role in MCC and may be a promising therapeutic target.
keywords:

CD8, EZH2, Merkel cell carcinoma, PD-1, PD-L1

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