Abstract
4/2021
vol. 37
Review article
A review of the mechanisms and biomarkers of allergen immunotherapy
- Student Research Group of Adult Allergology, Wroclaw Medical University, Wroclaw, Poland Head of the Group: Dr Krzysztof Gomułka
- Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, Wroclaw, Poland Head of the Department: Wojciech Barg MD, DSc
Medical Studies/Studia Medyczne 2021; 37 (4): 322–330
Online publish date: 2021/12/31
Allergen immunotherapy has been shown to be successful in numerous clinical trials, even leading to complete relief of allergic symptoms. However, the molecular mechanisms behind these outcomes remain unclear, substantially hindering introduction of more efficient and safer protocols. The current gold standard of assessing the effects of allergen immunotherapy is a challenge test, which might be both unpleasant and dangerous for patients. Better understanding of the molecular background of allergen immunotherapy would allow us to substitute challenge tests with biomarkers. These might also be used to predict a patient’s response to the treatment. Here, we review current knowledge regarding immune responses to allergen immunotherapy and its potential biomarkers.
Keywords
immunotherapy, allergy, desensitization
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