Abstract
2/2016
vol. 18
Original paper
Usefulness of urinary kidney injury molecule-1 (KIM-1) in children with idiopathic nephrotic syndrome treated with cyclosporine A
- Katedra i Klinika Nefrologii Pediatrycznej Uniwersytetu Medycznego we Wrocławiu
Family Medicine & Primary Care Review 2016; 18, 2: 103–108
Online publish date: 2016/06/27
Background. Some forms of idiopathic nephrotic syndrome (INS ) are treated with cyclosporine A (CsA) as an alternative method. A serious adverse effect of the drug is nephrotoxicity. To help optimize the therapy, researchers are looking for early kidney injury markers.
Objectives. To determine KI M-1 (kidney injury molecule-1) plasma and urine concentrations in children with INS and to evaluate the suitability of the protein as CsA nephrotoxicity marker.
Material and methods. 30 children with steroid-dependent (SDNS ) and steroid-resistant (SRNS ) INS and 22 healthy children were enrolled to the study. KI M-1 plasma and urine concentrations were determined in children with INS before the administration of CsA, and then after 6 and 12 months, using the enzyme-linked immunosorbent assay (ELISA ).
Results. In the INS group, higher KI M-1 plasma and urine concentration were observed prior to the administration of CsA compared to the reference group. During the follow-up period, KI M-1 plasma levels were increasing, and the values varied significantly at all time points. KI M-1 urine levels after 6 and 12 months of therapy were significantly higher compared to baseline, and statistically, did not vary significantly when determined between 6 and 12 months of treatment. No correlation was found between KI M-1 urine concentrations and CsA blood levels, proteinuria or eGFR. The parameters analysed in plasma and urine of SDNS and SRNS diagnosed patients, did not vary significantly.
Conclusions. Urine KI M-1 concentration were found to vary in INS children treated with CsA, which suggests that the protein may be suitable for monitoring these patients.
Objectives. To determine KI M-1 (kidney injury molecule-1) plasma and urine concentrations in children with INS and to evaluate the suitability of the protein as CsA nephrotoxicity marker.
Material and methods. 30 children with steroid-dependent (SDNS ) and steroid-resistant (SRNS ) INS and 22 healthy children were enrolled to the study. KI M-1 plasma and urine concentrations were determined in children with INS before the administration of CsA, and then after 6 and 12 months, using the enzyme-linked immunosorbent assay (ELISA ).
Results. In the INS group, higher KI M-1 plasma and urine concentration were observed prior to the administration of CsA compared to the reference group. During the follow-up period, KI M-1 plasma levels were increasing, and the values varied significantly at all time points. KI M-1 urine levels after 6 and 12 months of therapy were significantly higher compared to baseline, and statistically, did not vary significantly when determined between 6 and 12 months of treatment. No correlation was found between KI M-1 urine concentrations and CsA blood levels, proteinuria or eGFR. The parameters analysed in plasma and urine of SDNS and SRNS diagnosed patients, did not vary significantly.
Conclusions. Urine KI M-1 concentration were found to vary in INS children treated with CsA, which suggests that the protein may be suitable for monitoring these patients.
Keywords
children, cyclosporine A, idiopathic nephrotic syndrome, KI M-1
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