Relapsing polychondritis (RP) is a rare, multisystem, autoimmune disorder characterized by recurrent inflammation and destruction of the cartilage tissue of the external ear, nose, larynx, trachea, major bronchi and peripheral joints. RP can also involve other proteoglycan-rich structures, such as the eye, heart, blood vessels, inner ear and kidney. The diagnosis is made on the basis of modified Mc Adam criteria including chondritis in two of three sites (auricular, nasal, laryngotracheal) or one of those sites and two other features, including ocular inflammation, audiovestibular damage, or seronegative inflammatory arthritis. A biopsy is not recommended in most cases. We describe the case history of a 76-year-old male with multisymptomatic RP including SND and MR successfully treated in our department.