Full text
1/2024
vol. 40
Review article
Purinergic system in the pathogenesis and treatment of mood disorders
- Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland; Klinika Psychiatrii Dorosłych, Uniwersytet Medyczny w Poznaniu, Polska
Farmakoterapia w Psychiatrii i Neurologii 2024, 40 (1), 43–52
Data publikacji online: 2024/08/01
Article file
- Akhondzadeh S, Milajerdi MR, Amini H, Tehrani-Doost M. Allopurinol as an adjunct to lithium and haloperidol for treatment of patients with acute mania: A double-blind, randomized, placebo-controlled trial. Bipolar Disord 2006; 8: 485–489.
- Albert U, De Cori D, Aguglia A, Barbaro F, Bogetto F, Maina G. Increased uric acid levels in bipolar disorder subjects during different phases of illness. J Affect Disord 2015; 173: 170–175.
- Ai Y, Wang H, Liu L, Qi Y, Tang S, Tang J, Chen N. Purine and purinergic receptors in health and disease. MedComm 2023, 4, e359.
- Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale et.al. 2023. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br. J. Pharmacol 2023; 180, S23-S144.
- Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C et al. The P2X7 receptor: central hub of brain diseases. Front Mol Neurosci 2020; 13: 124.
- Bartoli F, Crocamo C, Mazza MG, Clerici M, Carrà G. Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis. J Psychiatr Res 2016; 81: 133–139. (a)
- Bartoli F, Crocamo C, Gennaro GM, Castagna G, Trotta G, Clerici M et al. Exploring the association between bipolar disorder and uric acid: A mediation analysis. J Psychosom Res 2016; 84: 56–59. (b)
- Bartoli F, Crocamo C, Dakanalis A, Brosio E, Miotto A, Capuzzi E et al. Purinergic system dysfunctions in subjects with bipolar disorder: A comparative cross-sectional study. Compr
- Psychiatry 2017;73:1–6. (a)
- Bartoli F, Crocamo C, Clerici M, Carrà G. Allopurinol as addon treatment for mania symptoms in bipolar disorder: systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry 2017; 210: 10–15. (b)
- Bartoli F, Trotta G, Crocamo C, Malerba MR, Clerici M, Carrà G. Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression. Eur Arch Psychiatry Clin Neurosci 2018; 268: 119–127. (a)
- Bartoli F, Crocamo C, Bava M, Castagna G, Di Brita C, Riboldi I et al. Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study. Psychiatry Res 2018; 269: 118–123. (b)
- Bartoli F, Crocamo C, Trotta G, Bava M, Capuzzi E, Castagna G et al. Testing the role of the antioxidant uric acid as a biomarker of suicidal ideation in subjects with major affective disorders: An exploratory study. Gen Hosp Psychiatry 2018; 51: 128–129. (c)
- Bartoli F, Burnstock G, Crocamo C, Carrà G. Purinergic signaling and related biomarkers in depression. Brain Sci 2020; 10: 160.
- Bernier LP. Purinergic regulation of inflammasome activation after central nervous system injury. J Gen Physiol 2012; 140: 575.
- Burnstock G. An introduction to the roles of purinergic signaling in neurodegeneration, neuroprotection and neuroregeneration. Neuropharmacology 2016; 104: 4–17.
- Cade J.F.K. Lithium salts in the treatment of psychotic excitement. Med J Aust, 1949; 36: 349–352.
- Chatterjee SS, Ghosal S, Mitra S, Mallik N, Ghosal MK. Serum uric acid levels in first episode mania, effect on clinical presentation and treatment response: Data from a case control study. Asian J Psychiatr 2018; 35: 15–17.
- Chen AT, Malmstrom T, Nasrallah HA. Allopurinol augmentation in acute mania: A meta-analysis of placebo-controlled trials. J Affect Disord 2018; 226: 245–250.
- Chung KH, Huang CC, Lin HC. Increased risk of gout among patients with bipolar disorder: A nationwide population- based study. Psychiatry Res 2010; 180 (2–3): 147–150.
- Garrod AB. Gout and Rheumatic Gout. Walton and Maberly, London 1859.
- Gonçalves MCB, Andrejew R, Gubert C. The purinergic system as a target for the development of treatments for bipolar disorder. CNS Drugs 2022; 36: 787–801.
- Grosso G, Micek A, Castellano S, Pajak A, Galvano F. Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies. Mol. Nutr. Food Res. 2016; 60: 223–234.
- Gubert C, Jacintho Moritz CE, Vasconcelos-Moreno MP, Quadros Dos Santos BTM, Sartori J, Fijtman A et al. Peripheral adenosine levels in euthymic patients with bipolar disorder. Psychiatry Res 2016; 246: 421–426.
- Gubert C, Andrejew R, Jacintho Moritz CE, Dietrich F, Vasconcelos- Moreno MP, Dos Santos BTMQ et al. Bipolar disorder and 1513A>C P2RX7 polymorphism frequency. Neurosci Lett 2019 Feb 16; 694: 143–147.
- Gubert C, Andrejew R, Leite CE, Moritz CEJ, Scholl J, Figueiro F et al. P2X7 purinergic receptor is involved in the pathophysiology of mania: a preclinical study. Mol Neurobiol 2020; 57: 1347–1360.
- Illes P, Rubini P, Ulrich H, Zhao Y, Tang Y. Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS. Cells 2020; 9: 1108.
- Illes P, Verkhratsky A, Tang Y. Pathological ATPergic signaling in major depression and bipolar disorder. Front Mol Neurosci 2020; 12: 331.
- Kaster MP, Rosa AO, Rosso MM, Goulart EC, Santos AR, Rodrigues AL. Adenosine administration produces an antidepressant- like effect in mice: Evidence for the involvement of A1 and A2A receptors. Neurosci Lett 2004; 355: 21–24.
- Lange C. Periodische Depressionzustände und ihre Pathogenesis auf dem Boden der harnsäuren Diathese. Verlag von Leopold Voss, Hamburg und Leipzig, 1886.
- Lintunen J, Lähteenvuo M, Tanskanen A, Tiihonen J, Taipale H. Allopurinol, dipyridamole and calcium channel blockers in the treatment of bipolar disorder – A nationwide cohort
- study. J Affect Disord 2022; 313: 43–48.
- Lovatt D, Xu Q, Liu W Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. PNAS 2020; 109: 62656270.
- Lucas M, O’Reilly EJ, Pan A, Mirzaei F, Willett WC, Okereke OI, Ascherio A. Coffee, caffeine, and risk of completed suicide: Results from three prospective cohorts of American adults. World J. Biol. Psychiatry 2014; 15: 377–386.
- Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G et al. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J. Clin. Psychiatry 2008; 69(8): 1237–1245.
- Malewska MK, Jasińska A, Rybakowski J. The therapeutic effects of lithium, a concept of purinergic theory in affective disorders. Farmakoterapia w Psychiatrii i Neurologii 2016; 32: 97–109.
- Malewska M, Permoda-Osip A, Kasprzak P, Niemiec A, Rybakowski J. A study of uric acid concentration in bipolar disorder and schizophrenia. Farmakoterapia w Psychiatrii i Neurologii 2017; 33: 185–187.
- Malewska-Kasprzak MK, Permoda-Osip A, Rybakowski J. Disturbances of purinergic system in affective disorders and schizophrenia. Psychiatr Pol. 2019; 53: 577–587.
- Malewska-Kasprzak M, Permoda A, Rybakowski JK. Dysfunction of the purinergic system in bipolar disorder. Neuropsychobiology 2022; 81: 265–270.
- Oliveira Rda L, Seibt KJ, Rico EP, Bogo MR, Bonan CD. Inhibitory effect of lithium on nucleotide hydrolysis and acetylcholinesterase activity in zebrafish (Danio rerio) brain. Neurotoxicol Teratol 2011; 33(6): 651–657.
- Padilla KM, Quintanar-Setephano A, López-Vallejo F, Berumen LC, Miledi R, García-Alcocer G. Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy. Brain Behav 2018; 8:e00952.
- Park H, Suh BS, Lee K. Relationship between daily coffee intake and suicidal ideation. J. Affect. Disord. 2019; 256: 468–472.
- Poleszak E, Szopa A, Bogatko K, Wyska E, Wośko S, Świąder K et al. Antidepressant-like activity of typical antidepressant drugs in the forced swim test and tail suspension test in mice is augmented by DMPX, an adenosine A(2A) receptor antagonist. Neurotox. Res. 2019; 35: 344–352.
- Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L et al. Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial. J Psychopharmacol 2023; 34: 1030–1042. (a)
- Recourt K, de Boer P, van der Ark P, Benes H, van Gerven JMA, Ceusters M et al. Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder. Transl Psychiatry 2023; 13: 266. (b)
- Salvadore G, Viale CI, Luckenbaugh DA, Zanatto VC, Portela LV, Souza DO et al. Increased uric acid levels in drug-naïve subjects with bipolar disorder during a first manic episode. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010; 34(6): 819–821.
- Sikka P, Behl T, Chandel P, Sehgal A, Singh S, Makeen HA et al. Scrutinizing the therapeutic promise of purinergic receptors targeting depression. Neurotox Res 2022; 40: 1570–1585.
- Szopa A, Bogatko K, Serefko A, Wyska E, Wośko S, Świąder K et al. Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist. Pharmacol Rep 2019; 71: 676–681.
- Szopa A, Socała K, Serefko A, Doboszewska U, Wróbel A, Poleszak E et al. Purinergic transmission in depressive disorders. Pharmacol Ther. 2021; 224: 107821.
- Voelker R. Add-on drug approved for “off” episodes of Parkinson disease. JAMA 2019; 322: 1246.
- Yamada K, Kobayashi M, Shiozaki S, Ohta T, Mori A, Jenner P et al. Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats. Psychopharmacology (Berl) 2014; 231: 2839–2849.
- Yu Y, Feng L, Li J, Lan X, L. A, X. Lv, Zhang M, Chen L. The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits. Behav Brain Res 2017; 334: 155–162.
- Zhao YF, Verkhratsky A, Tang Y, Illes P. Astrocytes and major depression: The purinergic avenue. Neuropharmacology 2022; 220: 109252.
