CLINICAL RESEARCH
Quality of life of patients with chronic obstructive pulmonary disease treated with indacaterol and/or glycopyrronium: a real-world Polish observational study
 
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Submission date: 2018-11-18
 
 
Final revision date: 2018-11-29
 
 
Acceptance date: 2018-11-29
 
 
Publication date: 2018-12-28
 
 
Arch Med Sci Civil Dis 2018;3(1):202-209
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of this study was to evaluate the impact of routinely administered treatment with indacaterol and/or glycopyrronium on quality of life and level of dyspnoea of patients with chronic obstructive pulmonary disease (COPD) in a real-life setting.

Material and methods:
It was an observational, non-interventional study in patients with stable, symptomatic chronic obstructive pulmonary disease initiating treatment with indacaterol and/or glycopyrronium as part of routine care. The primary outcomes included a change in quality of life measured using the Clinical COPD Questionnaire (CCQ) and level of dyspnoea evaluated using the modified Medical Research Council scale (mMRC). Patients were followed up for 6 months after initiation of treatment.

Results:
Analysis included baseline data from 586 patients. At 6 months 82.5% (n = 483) of patients were continuing initiated treatment. Improvement of mMRC and CCQ scores was observed in all treatment arms. The mean total CCQ score ± SD changed after 6 months from 2.2 ±0.9 to 1.2 ±0.9 in the indacaterol group (p < 0.001), from 2.1 ±1.0 to 1.0 ±0.9 (p < 0.001) in the glycopyrronium group and 2.6 ±1.1 at baseline to 1.3 ±1.0 (p < 0.001) in the indacaterol/glycopyrronium group. The mean mMRC ± SD decreased from 2.1 ±0.9 to 1.4 ±0.9 (p < 0.001) in the indacaterol group, from 2.1 ±0.9 to 1.2 ±1.0 (p < 0.001) in the glycopyrronium group, and from 2.3 ±0.8 to 1.4 ±0.9 (p < 0.001) in the indacaterol/glycopyrronium group.

Conclusions:
Use of indacaterol and/or glycopyrronium improved quality of life and breathlessness in patients with stable COPD, efficiently reducing the symptoms burden.

 
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ISSN:2451-0637
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