Abstract
3/2024
vol. 75
Case report
Quiz CORRECT ANSWER TO THE QUIZ. CHECK YOUR DIAGNOSIS Prostatic paraganglia-hyperplasia – a histological mimic of intraprostatic adipose tissue
- Department of General and Clinical Pathology, Medical University of Plovdiv, Bulgaria
- Department of Forensic Medicine, Medical University of Plovdiv, Bulgaria
- Department of Pathology, Military Medical Academy, Sofia, Bulgaria
- Department of Pathology, Jossigny Hospital, Jossigny, France
Pol J Pathol 2024; 75 (3): 256-258
Online publish date: 2024/07/10
Prostatic paraganglia (PP) can simulate adenocarcinoma’s fused gland pattern, and a differential diagnostic panel is developed. Their differential diagnosis with benign prostatic lesions has been largely unreported.
Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.
We present one case from 100 randomly selected radical prostatectomy specimens in which our diagnosis evolved from IPAT to PP-hyperplasia, after additional immunohistochemical investigations. The presence of PP-hyperplasia, with both parenchymal and neurovascular bundle location, and its differential diagnosis with IPAT has not been previously reported.
Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.
We present one case from 100 randomly selected radical prostatectomy specimens in which our diagnosis evolved from IPAT to PP-hyperplasia, after additional immunohistochemical investigations. The presence of PP-hyperplasia, with both parenchymal and neurovascular bundle location, and its differential diagnosis with IPAT has not been previously reported.
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