eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
1/2014
vol. 65
 
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abstract:

Quiz. Correct answer to the quiz. Check your diagnosis Hodgkin’s lymphoma mimicking tuberculosis in cervical lymph nodes

Anna Szumera-Ciećkiewicz
,
Monika Prochorec-Sobieszek
,
Ewa Lech-Marańda

Pol J Pathol 2014; 65 (1): 83-88
Online publish date: 2014/05/13
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The authors present a case description of an 81-year-old male with general symptoms (fever, night sweats, weight loss) and cervical/supraclavicular lymphadenopathy. The revised lymph node histopathological examination revealed nodular sclerosis classical Hodgkin’s lymphoma associated with abundant tuberculosis-mimicking granulomatous reaction. The diagnosis may be difficult due to similarities in clinical course, laboratory tests and imaging. The morphology of Hodgkin-Reed-Sternberg cells and the immunohistochemical profile are the most helpful in differential diagnosis. In cases where granulomas coexist with negative acid-fast staining, pathologists should always recommend evaluation of further and broader diagnostic procedures to exclude Mycobacterium tuberculosis infection.
keywords:

Hodgkin’s lymphoma, tuberculosis, granuloma, non-infectious granulomatous reaction

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