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Polish Journal of Pathology
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1/2014
vol. 65
 
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Quiz. WHAT IS YOUR DIAGNOSIS?

Pol J Pathol 2014; 65 (1): 89-89
Online publish date: 2014/05/13
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A 63-year-old male presented to our hospital with epistaxis. He is a heavy smoker with 40 cigarettes per day for 40 years. He had past history of hypertension under medical treatment. Several black nodules up to several millimeters were discovered at the nasopharynx during nasoscopic examination (Fig. 1). Microscopically, there were multiple small nodules composed of clusters of seromucinous glands under the overlying respiratory epithelium (Fig. 2A). The double-layered epithelium of these seromucinous glands showed diffuse oncocytic metaplasia with finely granular brown pigments in their cytoplasm (Fig. 2B). The brown pigments were stained positively for Fontana-Masson stain (Fig. 2C) and negative for Prussian blue stain. By immunohistochemistry, there were dendritic cells immunoreactive to S-100 protein and Melan-A (Fig. 2D), but not HMB-45.
Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan
2Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan
3Department of Otolaryngology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan
This work was partially supported by grants from E-DA Hospital (Grant number EDAHP103051).
Answers should be sent to the Editorial Office by 15.06.2014. The correct answer will be announced in the next issue of the Polish Journal of Pathology. All participants with the highest number of correct answers to the quizzes published in vol. 65 (4 issues) will be entered into the prize draw for a book.
Copyright: © 2014 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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