eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2012
vol. 63
 
Share:
Share:
more
 
 
abstract:

Rare association of polyneuropathy and Crohn’s disease: a clinicopathological study of 4 cases

Evangelia Kararizou
,
Panagiota Davaki
,
Konstantinos Speggos
,
Elevtherios Stamboulis

Pol J Pathol 2012; 63: 261-266
Online publish date: 2013/01/24
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
PlumX metrics:
The purpose of this study is to investigate the clinical, electrophysiological and pathological features of neuropathy in patients with Crohn’s disease.

Biopsies were selected from over 700 sural nerve biopsies. The diagnosis of Crohn’s disease was based on established clinicopathological criteria. Complete laboratory, clinical, electrophysiological and pathological studies were performed in all cases.

Nerve biopsies of 4 patients were diagnosed as neuropathy and Crohn’s disease. Distal symmetrical sensorimotor polyneuropathy was the pattern of neuropathy. The pathological features were mixed, demyelination with predominant axonal degeneration and a varying pattern of myelinated fiber loss. There were no vasculitic changes found.

We conclude that patients with Crohn’s disease are complicated frequently with polyneuropathy, and as remission depends on immunosuppressive therapy, it is important to recognise it in the early stage. The diagnosis of polyneuropathy is based on clinical and electrophysiological studies, but precise histology, immunohistochemistry and morphometric studies of the peripheral nerve biopsy may be decisive in establishing the diagnosis.
keywords:

Crohn’s disease, polyneuropathy, axonal degeneration, demyelination

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.