eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 44
Clinical immunology

Reduced GLP-1 response to a meal is associated with the CTLA4 rs3087243 G/G genotype

András Zóka
Gábor Barna
Gábor Nyírő
Ágnes Molnár
László Németh
Györgyi Műzes
Anikó Somogyi
Gábor Firneisz

(Centr Eur J Immunol 2019; 44 (3): 299-306)
Online publish date: 2019/09/30
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Although insulitis is the characteristic main feature of type 1 diabetes mellitus (T1DM), many aspects of β cell loss still remain elusive. Immune dysregulation and alterations in the dipeptidyl-peptidase-4-incretin system might have a role in disease development, but their connection is poorly understood. We assessed the associations of a few selected, immunologically relevant single nucleotide gene variants with the DPP-4-incretin system in individuals with T1DM and in healthy controls. Prandial plasma (total, active) GLP-1 levels, serum DPP-4 activity, CD25 and CTLA-4 expression of T cells and DPP4 rs6741949, CTLA4 rs3087243, CD25 rs61839660 and PTPN2 rs2476601 SNPs were assessed in 33 T1DM patients and 34 age-, gender-, BMI-matched non-diabetic controls without a family history of T1DM. CTLA-4 expression was lower in the Foxp3+CD25+ regulatory T cells from individuals homozygous for the CTLA4 rs3087243-G variant compared to those who carry an A allele. Prandial plasma total GLP-1 levels 45 min after a standardized meal were reduced in individuals homozygous for the CTLA4 rs3087243 G major allele compared to A allele carriers both in the entire study population (with statistical power over 90%) and within the T1DM group. Here we report for the first time a reduced total prandial GLP-1 plasma concentration in individuals with the CTLA4 rs3087243 G/G genotype. One may speculate that immune response-related L cell damage might possibly explain this novel association.

type 1 diabetes, GLP-1, autoimmune, CTLA4, incretin response, genetic, association study, SNPs, genetic susceptibility

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