Abstract
4/2023
vol. 98
Case report
Renal cell carcinoma or angiomyolipoma – diagnostic and therapeutic dilemmas in a 17-year-old female patient with tuberous sclerosis complex
- Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland
- Department of Neurology, Medical University of Warsaw, Warsaw, Poland
- Department of Paediatric Neurology, Medical University of Warsaw, Warsaw, Poland
- Department of Paediatric Radiology, Medical University of Warsaw, Warsaw, Poland
- Department of Pathomorphology, Medical University of Warsaw, Warsaw, Poland
Pediatr Pol 2023; 98 (4): 343-348
Online publish date: 2023/12/15
We present a case of a 17-year-old girl with tuberous sclerosis complex (TSC) with suspicion of renal cell carcinoma in the left kidney. Pathomorphological examination revealed domination of fusiform cells, and foci of adipocytes with a tendency towards perivascular proliferation. Immunohistochemistry revealed a positive reaction for markers of angiomyolipoma (AML): SMA (smooth muscle actin), HMB-45 (Human Melanoma Black-45), and MelanA (melanocyte antigen), and negative reaction for markers of renal cell carcinoma. In addition, positive reaction for TFE3 (transcription factor binding to immunoglobulin heavy-chain enhancer 3) was found in nuclei. The tumour was classified as a lipid-poor AML, and treatment with rapamycin was started in the patient. To the best of our knowledge, this is the first renal AML in a TSC patient in whom nuclear expression of TFE3 was found. Differential diagnosis of lipid-poor renal lesions in TSC patients is a demanding challenge requiring a dedicated, experienced multidisciplinary team.
Keywords
immunohistochemistry, renal cell carcinoma, tuberous sclerosis complex, lipid-poor angiomyolipoma
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