eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
Share:
Share:
more
 
 
abstract:
Clinical research

Retrospective cohort study of patients qualified for lung transplantation due to idiopathic pulmonary fibrosis – single-centre experience

Marek Ochman
,
Maciej Urlik
,
Zofia Tatoj
,
Fryderyk Zawadzki
,
Marta Wajda-Pokrontka
,
Magdalena Latos
,
Piotr Przybyłowski
,
Marian Zembala

Arch Med Sci
Online publish date: 2019/01/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease. Pharmacological treatment can only slow its progression. However, lung transplantation (LTx) is the only treatment for patients with its end-stage form. This study analysed the long-term results of the qualification process of patients with IPF recruited for LTx in a single centre.

Material and methods
Retrospective analysis of 84 patients (56 patients who died while on the waiting list and 28 patients who underwent LTx) with end-stage IPF who were qualified for LTx between 2006 and 2017 at the Silesian Centre for Heart Diseases (Zabrze, Poland).

Results
Cox proportional hazard analysis showed that the only parameter was 6-minute walk test (6MWT) distance, which statistically significantly impacted the probability of receiving a graft (parameter assessment, 0.00523; p = 0.006; 95% confidence interval (CI): 0.0015–0.009; hazard ratio (HR) = 1.005) as well as that of death while on the waiting list (parameter assessment, –0.0054; p = 0.003; 95% CI: –0.009– (–0.0017); HR = 0.995). Patients with a 253–350-m 6MWT distance had 3 times greater risk of dying while on the waiting list than those who walked more than 350 m. Other factors, such as height, sex, and blood group, also influenced the outcome.

Conclusions
The 6-minute walk test distance is an independent predictor of mortality on the lung transplant waiting list. Blood type and height also play a significant role in becoming a lung recipient.

keywords:

idiopathic pulmonary fibrosis, interstitial lung diseases, lung transplantation, qualification, mortality

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe