eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
1/2015
vol. 32
 
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abstract:

Review paper
Amorolfine vs. ciclopirox – lacquers for the treatment of onychomycosis

Katarzyna Tabara
,
Anna E. Szewczyk
,
Wojciech Bienias
,
Agnieszka Wojciechowska
,
Marta Pastuszka
,
Magdalena Oszukowska
,
Andrzej Kaszuba

Postep Derm Alergol 2015; XXXII, 1: 40–45
Online publish date: 2015/02/03
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Amorolfine 5% and ciclopirox 8% nail lacquers are commonly used in topical treatment of onychomycosis. These formulations may be used alone or in combination with oral antifungal agents. Amorolfine and ciclopirox are valuable therapeutic options, however, their usage in monotherapy should be limited. Proper amorolfine and ciclopirox penetration through the nail plate is provided by transungual drug delivery systems. Although amorolfine and ciclopirox have a different mode of action, they both exhibit a broad antifungal activity. The use of antifungal nail lacquers in combination with oral agents, such as terbinafine and itraconazole, improves efficacy of antifungal therapy.
keywords:

onychomycosis, amorolfine, ciclopirox, lacquer

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