eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
3/2014
vol. 31
 
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abstract:

Review paper
Cardiovascular safety of antihistamines

Anna Olasińska-Wiśniewska
,
Jerzy Olasiński
,
Stefan Grajek

Postep Derm Alergol 2014; XXXI, 3: 182–186
Online publish date: 2014/06/13
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Histamine is a mediator, which increases the permeability of capillaries during the early phase of allergic reaction, causes smooth muscle contraction of bronchi and stimulates mucous glands in the nasal cavity. Antihistamines are the basis of symptomatic treatment in the majority of allergic diseases, especially allergic rhinitis, allergic conjunctivitis, urticaria and anaphylaxis. The cardiotoxic effects of the two withdrawn drugs, terfenadine and astemizole, were manifested by prolonged QT intervals and triggering torsades de pointes (TdP) caused by blockade of the ‘rapid’ IKr potassium channels. These phenomena, however, are not a class effect. This review deals with a new generation of antihistamine drugs in the context of QT interval prolongation risk.
keywords:

histamine, H1 receptor, antihistamines, QT interval, torsades de pointes

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