eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
3/2009
vol. 5
 
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abstract:

Review paper
Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes?

Glyn Wainwright, Luca Mascitelli, Mark R. Goldstein

Arch Med Sci 2009; 5, 3: 289-295
Online publish date: 2009/10/22
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Current guidelines encourage ambitious long term cholesterol lowering with statins, in order to decrease cardiovascular disease events. However, by regulating the biosynthesis of cholesterol we potentially change the form and function of every cell membrane from the head to the toe. As research into cell morphology and membrane function realises more dependencies upon cholesterol rich lipid membranes, our clinical understanding of long term inhibition of cholesterol biosynthesis is also changing. This review of non-cardiovascular research concerning such membrane effects raises important new issues concerning the clinical advantages and disadvantages of the long term use, and broadening criteria, of cholesterol reductions.
keywords:

cholesterol, exocytosis, lipid, membrane, statin

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