Review paper<br>Dual role of Th17 cells in Crohn’s disease

Jacek Karczewski; Maciej Mazur; Marek Karczewski

doi:10.5114/ceji.2012.30808

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2012
vol. 37

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abstract:

Review paper
Dual role of Th17 cells in Crohn’s disease

Jacek Karczewski

,

Maciej Mazur

,

Marek Karczewski

(Centr Eur J Immunol 2012; 37 (3): 286-289)

DOI: https://doi.org/10.5114/ceji.2012.30808

Online publish date: 2012/10/27

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Crohn’s disease (CD) is a chronic relapsing, destructive inflammatory disease of the gastrointestinal (GI) tract, the cause of which remains still unknown. Accumulating evidence suggests that CD results from the imbalance between pro- and anti-inflammatory agents and the overactivity of T helper (Th)1. It seems that major cause of GI inflammation is an IL-12-driven Th1 response, which results in the generation of IFN-γ, the key inflammatory mediator. Recently, however, much attention has also been given to the possible involvement of Th17 cells in the pathogenesis of CD. This mini-review is aimed to summarize the current knowledge on the dual role of Th17 cells in CD.

keywords:

Review paperDual role of Th17 cells in Crohn’s disease

Jacek Karczewski , Maciej Mazur , Marek Karczewski

IBD, Crohn’s disease, Th17, IL-17, Th1/Th2/Th17

Review paper
Dual role of Th17 cells in Crohn’s disease

Jacek Karczewski

,

Maciej Mazur

,

Marek Karczewski