eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2012
vol. 37
 
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abstract:

Review paper
Mechanisms of the innate immunity in the respiratory system

Katarzyna Grzela
,
Wioletta Zagórska
,
Tomasz Grzela

(Centr Eur J Immunol 2012; 37 (3): 280-285)
DOI: https://doi.org/10.5114/ceji.2012.30807
Online publish date: 2012/10/27
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The respiratory system is permanently exposed to the influence of numerous harmful environmental factors: various microbial pathogens, allergens and air pollution, with non-volatile toxic chemicals of tobacco smoke. Therefore, there have been developed several mechanisms protecting from these factors. These mechanisms can be classified as innate, non-specific, or acquired, much more specific, which are associated with regular immune response. In this review authors shortly describe the innate, non-specific mechanisms, which compose the first line of antimicrobial defense in our respiratory system. The mechanisms of innate immunity include passive protection, provided by the mucus-mediated mechanical barrier. Moreover, by means of active defense, several potent immunoregulatory factors and various substances displaying antibacterial, antifungal and antiviral activity are also engaged.
keywords:

antimicrobial peptides, ciliated epithelium, innate immunity, mucus, respiratory tract

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