eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2013
vol. 38
 
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abstract:

Review paper
Psoriasis as a disease associated with the immune system disorders

Dorota Chomiczewska-Skóra
,
Ewa Trznadel-Grodzka
,
Helena Rotsztejn

(Centr Eur J Immunol 2013; 38 (1): 129-133)
Online publish date: 2013/04/18
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The etiopathogenesis of psoriasis has not been fully elucidated. Nowadays, psoriasis is perceived as a multifactorial disease of genetic origin, in which complex immunological disorders concerning specific and non-specific defense mechanisms play a key role. Researchers emphasize the systemic and inflammatory character of the disease, its autoimmunological aspect and, above all, its dependence on T cells – Th1, Th17 and recently Th22. T cells with type 1 cytokine profile (Th1 and Tc1), Th17 and Th22 lymphocytes, regulatory T cells, NK and NK-T cells, antigen-presenting cells (dendritic cells, including Langerhans cells), keratinocytes, neutrophils, monocytes and makrophages are among the cells that take part in the pathogenesis of psoriasis.
keywords:

psoriasis, lymphocytes, dendritic cells, cytokines

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