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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2007
vol. 45
 
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abstract:

Review paper
The role of substance P in rheumatoid arthritis

Barbara Lisowska

Reumatologia 2007; 45: 5: 290-293
Online publish date: 2007/10/31
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In recent years our knowledge of the role of neuropeptides in the pathogenesis of rheumatic diseases has expanded. Rheumatoid arthritis is a serious inflammatory disease of the distal joints that has a possible neurogenic component underlying its pathology. The author presents an overview of the metabolism and pharmacokinetics of substance P. The neuropeptide substance P is one possible mediator of this interaction, since it can be released into joint tissues from primary sensory nerve fibres. The peptide neurotransmitter substance P is released from the peripheral terminals of nociceptive afferent neurons and can produce physiological changes associated with acute and chronic inflammation.
keywords:

substance P, rheumatoid arthritis







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