eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
 
2/2006
vol. 44
 
Share:
Share:
more
 
 
abstract:

Review paper
The ups and downs of non-steroidal anti-inflammatory drugs

Barbara Lisowska
,
Maria Rell-Bakalarska
,
Lidia Rutkowska-Sak

Ru 2006; 44, 2: 106-111
Online publish date: 2006/04/28
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Conventional non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the metabolism of arachidonic acid to proinflammatory prostaglandins (PGs) by cyclooxygenase COX-1 and COX-2. Non-steroidal anti-inflammatory drugs provide important analgesic and anti-inflammatory benefits to millions of patients, but are associated with a number of serious adverse events. These include gastrointestinal toxicity, renal impairment, cardiovascular and thromboembolic complications. The mechanism underlying the serious complications associated with conventional NSAIDs and selective cyclooxygenase COX-2 inhibitors treatment is more complicated than simple imbalance between COX-1 and COX-2 inhibition and still is not clear. A recent opinions on benefit-risk balance associated with NSAIDs treatment are presented in this report
keywords:

non-steroidal anti-inflammatory drugs (NSAIDs), mechanism of action, benefit-risk balance







Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe