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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2012
vol. 50
 
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abstract:
Review paper

Role of endothelial progenitor cells and redox potential in synovium neovascularisation

Przemysław Rzodkiewicz
,
Michał Gajewski
,
Sławomir Maśliński
,
Elżbieta Wojtecka-Łukasik

Reumatologia 2012; 50, 5: 432–437
Online publish date: 2012/11/06
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Increased neovascularization of synovium is a significant element of pathogenesis of rheumatoid arthritis (RA). One of the factors that influence the course of the pathological process is production of reactive oxygen species which influence both the neovascularization process and endothelial progenitor cells metabolism. Abnormalities in production of reactive oxygen species in the course of inflammation may be not only a cause of damage observed in RA, but also one of the factors affecting the course of disease. This publication presents the current state of knowledge about the process of neovascularization, with particular discussion of the importance of redox potential.
keywords:

synovium neovascularisation, NADPH oxidase, redox, endothelial progenitor stem cells







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