en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


1/2005
vol. 43
 
Share:
Share:
abstract:

Role of hydroxymethyl-glutharyl CoA reductase inhibitors (statins) in rheumatology

Przemysław J. Kotyla
,
Bogna Śliwińska-Kotyla
,
Maciej Lewicki
,
Eugeniusz J. Kucharz

Reumatologia 2005; 43, 1: 21–25
Online publish date: 2005/03/14
View full text Get citation
 
Inhibitors of hydroxymethylglutaryl CoA reductase are characterized by very high efficacy in primary or secondary prevention and treatment of cardiovascular disorders. In last years, the evidence was accumulated suggesting that action of statins go far beyond only cholesterol lowering activity. These properties are sometimes called pleiotropic effects and suggested to be independent from lowering cholesterol activity. They include influence upon bone formation, endothelial function, prevention from dementia and effect upon cellular and humoral immunity. Connective tissue disorders are associated with rapid progression of atherosclerotic lesions. Taking into consideration ability of statins to slow down the progression of atherosclerosis as well as their immunosupressive properties, it is suggested to initiate hypolipemic treatment of the patients with this group of compounds. In this paper, we reviewed potential usefulness of statins in rheumatology. The special emphasis was put on targets and mechanism of action of this group of drugs.
keywords:

statins, pleiotropic effects, connective tissue diseases




Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.