eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
6/2021
vol. 38
 
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abstract:
Review paper

SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak
1
,
Marek Brzosko
1

1.
Department of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland
Adv Dermatol Allergol 2021; XXXVIII (6): 937–942
Online publish date: 2020/07/23
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Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different spectrums: pustulo-psoriatic hyperostotic spondyloarthritis and chronic recurrent multifocal osteomyelitis. The typical skin lesions are palmoplantar pustulosis and acne. The sign of arthritis is involvement of the anterior chest wall, most often the sternoclavicular joints. There are no standard treatment recommendations, but nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, antibiotics and biological drugs can be considered.
keywords:

synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO), pathogenesis, clinical presentation, imaging, comorbidities, treatment

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