Introduction:

Bullous pemphigoid is an autoimmune blistering disease with a complex etiology. It affects mostly elderly individuals and can be triggered by several factors, including comorbidities, medications, infections and physical factors. The clinical picture is characterized by erythema and urticarial lesions, tense blisters and severe pruritus. Skin lesions are very rarely located in typical seborrheic areas and such a variant is referred to as seborrheic pemphigoid.

Case report:

A 41-year-old female patient was referred to the Department of Dermatology and Venerology with erythematous macules, vesicles and bullae filled with serous fluid or hemorrhagic fluid and distributed on the skin of the face and chest. On direct immunofluorescence, immunoglobulins and complement deposits at the basement membrane zone were found.

Conclusions:

The diagnosis of seborrheic pemphigoid was made. This is a rare disease that should be differentiated from seborrheic dermatitis. Indirect and direct immunofluorescence tests may be helpful in the differential diagnosis.