eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2014
vol. 39
 
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abstract:

Serial ImmuKnow assay in stable kidney transplant recipients

Hyung Hwan Moon
,
Tae-seok Kim
,
Sanghoon Lee
,
Sanghyun Song
,
Milljae Shin
,
Jae Berm Park
,
Jong Man Kim
,
Hye Ryoun Jang
,
Wooseong Huh
,
Jae-Won Joh
,
Sung Joo Kim

(Centr Eur J Immunol 2014; 39 (1): 96-99)
DOI: https://doi.org/10.5114/ceji.2014.42132
Online publish date: 2014/04/22
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Objectives: The ImmuKnow assay (cylex Inc., Columbia, MD) has been reported to measure the global immune monitoring tool for organ transplantation recipients. We assess immuKnow ATP values in stable kidney transplant patients.

Material and methods: Patients who were kidney transplanted between September 2008 and May 2011 were enrolled in the prospective serial ImmuKnow assay study. The criteria of inclusion were living donor kidney transplantation (KT), no evidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and PRA less than 50%. ImmuKnow assay monitoring was performed at one day before operation, post operative weeks 4, 8, 12, 16, 20, 24, 36 and 52. We excluded patients who had undergone infectious syndrome or rejection episodes during the follow-up period.

Results: Among 71 patients who were enrolled in prospective serial ImmuKnow assay monitoring, 37 patients were proven to stable KT patients during the follow-up period. Two hundred and twenty-four samples from 37 patients were collected. ImmuKnow value and immunosuppression drug level were compared in post operative weeks 4, 8, 12, 16, 20, 24, 36 and 52. The value of ImmuKnow assay was significantly different depending on the length of time after transplant (p = 0.038). Interestingly, the pre-transplant ImmuKnow values were lower than those of the immediate post-transplant period.

Conclusions: the ImmuKnow value of stable KT recipients is different according to “time after transplant”. Therefore, “time after transplant” should be considered when applying an ImmuKnow assay in clinical practice.
keywords:

immune monitoring, kidney transplantation, immunosuppression

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