eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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1/2020
vol. 37
 
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abstract:

Serum concentration of interleukin 6 is related to inflammation and dyslipidemia in patients with psoriasis

Aldona Pietrzak
,
Paweł Chabros
,
Ewelina Grywalska
,
Daniel Pietrzak
,
Grzegorz Kandzierski
,
Bartłomiej Wawrzycki
,
Jacek Roliński
,
Krzysztof Gawęda
,
Dorota Krasowska

Adv Dermatol Allergol 2020; XXXVII (1): 41-45
Online publish date: 2018/09/05
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Introduction
Patients with psoriasis and psoriatic arthritis (PsA) have metabolic disturbances, which may be due to chronic inflammation.

Aim
Because interleukin-6 (IL-6) regulates both metabolic and inflammatory processes, we evaluated IL-6 as a potential marker of inflammation and metabolic disturbances in psoriasis.

Material and methods
This study involved 93 patients with psoriasis, including 31 patients with concurrent PsA. We investigated whether serum markers of lipid metabolism and inflammation, including IL-6, were related to each other and to disease activity.

Results
We found that concurrent PsA was associated with higher serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and IL-6. In patients with psoriasis alone, the IL-6 serum concentration correlated positively with the concentrations of TC and LDL-c and with erythrocyte sedimentation rates (ESRs). Moreover, IL-6 concentrations tended to correlate positively with the percentage of the body area affected by psoriatic lesions. Among all patients, those with normal blood lipids had lower ESRs and IL-6 concentrations than patients with abnormal blood lipids. A logistic regression model showed that PsA, Psoriasis Area Severity Index (PASI), and ESR were significant predictors of the serum IL-6 concentration.

Conclusions
Interleukin-6 may be an indicator of inflammatory activity in psoriasis. Moreover, IL-6 may be related to lipid abnormalities in patients with this disease.

keywords:

psoriasis, psoriatic arthritis, serum interleukin 6, lipids

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