Abstract
5/2022
vol. 39
Original paper
Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis
- Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
Adv Dermatol Allergol 2022; XXXIX (5): 959-964
Online publish date: 2022/03/03
Introduction
Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).
Aim
To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the –9894 T/C (rs1929992) and –11877 C/T (rs10975519) loci and the course of AD.
Material and methods
The study group consisted of 191 patients with AD and 168 controls.
Results
The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24–35.99, p = 0.01).
Conclusions
The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.
Keywords
IL-33; atopic dermatitis; polymorphism
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