Abstract
3-4/2015
vol. 10
Original paper
Serum melatonin levels in patients with traumatic brain injury-induced coma
Neuropsychiatria i Neuropsychologia 2015; 10, 3–4: 91–94
Online publish date: 2016/02/05
Introduction: Melatonin (MLT) is a known antioxidant. We present here the changes of serum melatonin levels in adult patients with traumatic brain injury (TBI)-induced coma.
Material and methods: Sixty-one adult patients with TBI-induced coma, assessed according to Glasgow Coma Scale (GCS) scores on admission, were divided into very severe injury, severe injury and moderate injury groups. Thirty-one adult healthy volunteers were selected as the control group. Blood samples were collected twice at day 1,
day 3 and day 7 after admission. The prognosis of these patients was evaluated 3 months after TBI.
Results: The serum MLT levels of each TBI group at each time point were significantly lower than those of the control group (p < 0.05). The MLT levels of very severe and severe TBI groups were significantly lower than those of the moderate TBI group (p < 0.05). The MLT level of the very severe group was significantly lower than that of the severe group (p < 0.05). The lower the serum MLT level, the more severe was the condition of TBI (by GCS scoring), and the lower were the Glasgow Outcome Scale (GOS) scores.
Conclusions: Lower serum MLT levels may indicate worse condition, and serum melatonin levels may correlate with the severity and prognosis of patients with TBI.
Material and methods: Sixty-one adult patients with TBI-induced coma, assessed according to Glasgow Coma Scale (GCS) scores on admission, were divided into very severe injury, severe injury and moderate injury groups. Thirty-one adult healthy volunteers were selected as the control group. Blood samples were collected twice at day 1,
day 3 and day 7 after admission. The prognosis of these patients was evaluated 3 months after TBI.
Results: The serum MLT levels of each TBI group at each time point were significantly lower than those of the control group (p < 0.05). The MLT levels of very severe and severe TBI groups were significantly lower than those of the moderate TBI group (p < 0.05). The MLT level of the very severe group was significantly lower than that of the severe group (p < 0.05). The lower the serum MLT level, the more severe was the condition of TBI (by GCS scoring), and the lower were the Glasgow Outcome Scale (GOS) scores.
Conclusions: Lower serum MLT levels may indicate worse condition, and serum melatonin levels may correlate with the severity and prognosis of patients with TBI.
Keywords
melatonin, traumatic brain injury, coma, GOS, prognosis
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