eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
4/2020
vol. 16
 
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Obstetrics and gynaecology
abstract:
Systematic review/Meta-analysis

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis

Lanling Wang
1
,
Chunlei Zhang
2
,
Yuhuan Song
3
,
Zhennan Zhang
4

1.
Maternity Department, W.F. Maternity and Child Care Hospital, Weicheng District, China
2.
Neonatology Department, Weifang Medical University, Weicheng District, China
3.
Pharmacy Department, W.F. Maternity and Child Care Hospital, Weifang, Weicheng District, China
4.
Public Computer Center, Weifang Medical University, Weifang, Kuiwen District, China
Arch Med Sci 2020; 16 (4): 742–751
Online publish date: 2020/04/15
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Introduction
This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D.

Material and methods
PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed.

Results
The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = –0.71, 95% CI: –0.91, –0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07–1.23). Vitamin D was negatively correlated with HOMA-IR (r = –0.62, 95% CI: –0.85, –0.39). The analysis showed no publication bias (Egger’s: p = 0.197; Begg’s: p = 0.786).

Conclusions
Vitamin D is closely associated with the onset of GDM.

keywords:

vitamin D, gestational diabetes mellitus, 25(OH)D, meta-analysis

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