OBSTETRICS AND GYNAECOLOGY / SYSTEMATIC REVIEW/META-ANALYSIS
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D.

Material and methods:
PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed.

Results:
The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = –0.71, 95% CI: –0.91, –0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07–1.23). Vitamin D was negatively correlated with HOMA-IR (r = –0.62, 95% CI: –0.85, –0.39). The analysis showed no publication bias (Egger’s: p = 0.197; Begg’s: p = 0.786).

Conclusions:
Vitamin D is closely associated with the onset of GDM.

eISSN:1896-9151
ISSN:1734-1922
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