eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2019
vol. 15
 
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abstract:
Experimental research

Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model

Mustafa B. Sayhan
,
Serhat Oguz
,
Ömer Salt
,
Nuray Can
,
Taner Ozgurtas
,
Tulın D. Yalta

Arch Med Sci 2019; 15 (6): 1582–1588
Online publish date: 2018/12/10
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Introduction
Mesenteric ischemia/reperfusion (I/R) injury is a serious clinical condition. There were a lot of experimental studies performed in the treatment of I/R injury. To our knowledge, this is the first experimental study with effects of sesamin on I/R injury model. We aimed to investigate the protective effect of sesamin on mesenteric I/R injury model.

Material and methods
A total of 32 male Sprague-Dawley rats were divided into four groups. Control group: superior mesenteric artery (SMA) exposed without clamping. I/R group: SMA was clamped for 60 min and then reperfused for 2 h. Sesamin group (S): 30 mg/kg sesamin were given for 5 days, and SMA exposed without clamping. I/R + S group: 30 mg/kg sesamin were given for 5 days, SMA was clamped for 60 min, and then reperfused for 2 h. Plasma and tissue oxidant parameters were investigated as well as histopathological evaluation.

Results
Plasma and tissue total antioxidant status (TAS) levels were significantly higher in I/R + S group compared to the rest (p < 0.005). The plasma TAS levels in I/R group was significantly low. The highest tissue TAS levels were detected in I/R + S group. The high levels of plasma and tissue TOS were found in I/R + S group. Plasma and tissue OSI levels were significantly higher in I/R group. Histopathologic evaluation showed that the mean level of intestinal tissue injury score in I/R group was 2.75 and 1.38 in I/R + S group.

Conclusions
Sesamin helps to protect the intestinal tissue at the cellular level by reducing the oxidative stress and inflammation at both the plasma and tissue levels in the experimental I/R model.

keywords:

mesenteric ischemia reperfusion, sesamin, oxidant parameters, rat

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