eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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SCImago Journal & Country Rank
 
1/2019
vol. 57
 
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Opis przypadku

Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease

Svitlana Smiyan
1
,
Igor Galaychuk
2
,
Igor Zhulkevych
2
,
Volodymyr Nykolyuk
3
,
Roman Komorovsky
1
,
Sofiya Gusak
1
,
Ivan Bilozetsky
4

1.
2nd Department of Internal Medicine, Ivan Horbachevsky Ternopil State Medical University, Ukraine
2.
Department of Oncology and Radiology, Ivan Horbachevsky Ternopil State Medical University, Ukraine
3.
Department of Pathohistology, Ternopil Regional Oncology Center, Ukraine
4.
Department of Surgical Dentistry, Ivan Horbachevsky Ternopil State Medical University, Ukraine
Data publikacji online: 2019/02/28
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Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren’s syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder. Further laboratory testing confirmed the presence of Lyme borreliosis. Effectiveness of the administered antibiotic therapy confirmed Borrelia burgdorferi infection. Interrelationships between Sjögren’s syndrome, lymphadenopathy and Lyme disease are discussed.




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