ISSN: 2451-0629
Archives of Medical Science - Atherosclerotic Diseases
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Official journal of the International Lipid Expert Panel (ILEP)
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1/2021
vol. 6
 
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abstract:
Letter to the Editor

Smoking and oxidised high-density lipoprotein: a preliminary report

Kazuhiko Kotani
1
,
Kouichi Miura
2

1.
Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Japan
2.
Division of Gastrenterology, Jichi Medical University, Shimotsuke-City, Japan
Arch Med Sci Atheroscler Dis 2021; 6: e28–e29
Online publish date: 2021/04/08
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Cigarette smoking is a risk factor for cardiovascular disease [1]. While various mechanisms are involved in this association, the reduction in the circulating level of high-density lipoprotein (HDL), a protective factor against cardiovascular disease, by smoking is well known [1]. Furthermore, smoking is a source of oxidants, leading to oxidative modification of in vivo molecules [1], and HDL is modified oxidatively as oxidised HDL (oxHDL) [2]. Because oxHDL lacks the native HDL function (i.e. suppression of the antioxidative function of apolipoprotein A-I, inhibition of ABCA1-dependent cholesterol efflux from atheromatous lesions) [1–3], the oxHDL behaviour may explain the association among smoking, HDL and cardiovascular disease.
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