LETTER TO THE EDITOR
Smoking and oxidised high-density lipoprotein: a preliminary report
 
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1
Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Japan
 
2
Division of Gastrenterology, Jichi Medical University, Shimotsuke-City, Japan
 
 
Submission date: 2021-01-06
 
 
Acceptance date: 2021-01-06
 
 
Publication date: 2021-04-08
 
 
Arch Med Sci Atheroscler Dis 2021;6(1):28-29
 
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ABSTRACT
Cigarette smoking is a risk factor for cardiovascular disease [1]. While various mechanisms are involved in this association, the reduction in the circulating level of high-density lipoprotein (HDL), a protective factor against cardiovascular disease, by smoking is well known [1]. Furthermore, smoking is a source of oxidants, leading to oxidative modification of in vivo molecules [1], and HDL is modified oxidatively as oxidised HDL (oxHDL) [2]. Because oxHDL lacks the native HDL function (i.e. suppression of the antioxidative function of apolipoprotein A-I, inhibition of ABCA1-dependent cholesterol efflux from atheromatous lesions) [1–3], the oxHDL behaviour may explain the association among smoking, HDL and cardiovascular disease.
ISSN:2451-0629
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