eISSN: 1896-9151
ISSN: 1734-1922
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abstract:
Short communication

Spectrum of ALDH1 mRNA in smokers and non-smokers with adenocarcinoma or squamous cell lung carcinoma

Da-Hua Liu
,
Fei-Fei Mou
,
Fu Ren
,
Pu Xia

Online publish date: 2019/01/16
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Introduction
Non-small cell lung carcinoma (NSCLC), which includes large cell lung cancer, lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD), is the leading cause of cancer-related death. Higher expression of ALDH1 family members (ALDH1A1-3) has been confirmed in many cancers, including lung cancer.

Material and methods
In this study, we used Oncomine database analysis and Kaplan-Meier plotter analysis to evaluate the expression levels and the prognostic roles of ALDH1 mRNA in smokers and non-smokers with LUSC or LUAD.

Results
We found that ALDH1A1 mRNA was higher in the LUSC tissues of smokers than that in non-smokers. ALDH1A3 mRNA was significantly lower in the LUSC tissues of smokers than that in non-smokers. Kaplan-Meier analysis revealed that ALDH1A1 mRNA was a benign indicator of non-smokers with LUAD.

Conclusions
ALDH1A1 mRNA could be used as a favorable marker of non-smokers with LUAD.

keywords:

lung cancer, ALDH1A1, smoker

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