eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
4/2012
vol. 8
 
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abstract:

State of the art paper
APOE gene polymorphisms and diabetic peripheral neuropathy

Christodoulos Monastiriotis
,
Nikolaos Papanas
,
Stavroula Veletza
,
Efstratios Maltezos

Arch Med Sci 2012; 8, 4: 583-588
Online publish date: 2012/09/08
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Genetic factors may influence the natural course of diabetic peripheral neuropathy and explain some of its variability. The aim of this review was to examine the association between apolipoprotein E (apoE) gene polymorphisms and diabetic peripheral neuropathy. Four relevant studies were identified. The two earlier works provided evidence that the ε4 allele is a risk factor for this complication, while the two more recent studies were negative. Important differences in the methodology used and in the populations included are obvious, rendering difficult the comparison between studies. In conclusion, the association between APOE gene polymorphisms and diabetic peripheral neuropathy is still unclear. Available evidence is rather limited and results have so far been contradictory. Future studies should employ more robust methodology, adjusting for potential confounders and for the prevalence of neuropathy in the general population with diabetes.
keywords:

apolipoprotein E, diabetes mellitus, diabetic neuropathy, polymorphisms

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