eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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2/2013
vol. 9
 
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abstract:

State of the art paper
Biochemistry of adipose tissue: an endocrine organ

Marisa Coelho, Teresa Oliveira, Ruben Fernandes

Arch Med Sci 2013; 9, 2: 191-200
Online publish date: 2013/02/10
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Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor a (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example). This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.
keywords:

adipose tissue, adipocytes, adipokines

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