eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
1/2013
vol. 9
 
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abstract:

State of the art paper
Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated phospholipase A2 and carboxyl ester lipase lipases in atherosclerotic plaque formation

Paweł Burchardt
,
Jakub Żurawski
,
Bartosz Zuchowski
,
Tomasz Kubacki
,
Dawid Murawa
,
Krzysztof Wiktorowicz
,
Henryk Wysocki

Arch Med Sci 2013; 9, 1: 151-158
Online publish date: 2013/02/10
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An increased level of low-density lipoprotein (LDL) is a very well established risk factor of coronary artery disease (CAD). Unoxidized LDL is an inert transport vehicle of cholesterol and other lipids in the body and is thought to be atherogenic. Recently it has been appreciated that oxidized products of LDL are responsible for plaque formation properties previously attributed to the intact particle. The goal of this article is to review the recent understanding of the LDL oxidation pathway. The role of oxidized products and key enzymes (lipoprotein-associated phospholipase A2 and carboxyl ester lipase) are also extensively discussed in the context of clinical conditions.
keywords:

carboxyl ester lipase, lipoprotein-associated phospholipase A2, atherosclerosis, lipoproteins

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