en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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1/2022
vol. 60
 
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abstract:
Review paper

Statin-induced necrotizing autoimmune myopathy: a systematic review

Manoj Kumar Reddy Somagutta
1, 2
,
Nishat Shama
3
,
Maria Kezia Lourdes Pormento
4
,
Ravi Pankajbhai Jagani
5
,
Ngaba Neguemadji Ngardig
6
,
Klodin Ghazarian
1
,
Greta Mahmutaj
7
,
Khaled El-Faramawy
8
,
Ashwini Mahadevaiah
9
,
Molly Sanjay Jain
10

1.
Department of Medicine, Avalon University School of Medicine, Willemstad, Curaçao
2.
Department of Clinical and Translational Research, Larkin Community Hospital, South Miami, USA
3.
Department of Research, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka, Bangladesh
4.
Department of Medicine, Ateneo School of Medicine and Public Health, 1604 Metro Manila, Philippines
5.
Department of Medicine, All Saints University College of Medicine, Kingstown, Saint Vincent, and the Grenadines, Canada
6.
Department of Research, Bon Samaritain Hospital, quartier Walia, N’Djamena, Chad
7.
Department of Medicine, Albanian American Medical Society, Health Center, University of Tirana, Albania
8.
Department of Medicine, El-Salam Port Said Hospital, Cairo, Egypt
9.
Department of Research, JSS Medical College, Mysore, Karnataka, India
10.
Department of Medicine, Saint James School of Medicine, Illinois, USA
Reumatologia 2022; 60, 1: 63–69
Online publish date: 2022/02/28
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Statins are a class of lipid-lowering medications used worldwide by millions of people and are safe for frequent use in most patients. However, they cause necrotizing autoimmune myopathy in some patients. We reviewed case reports of 80 patients from 2010 to present diagnosed with statin-induced necrotizing autoimmune myopathy (SINAM), aiming to analyze the clinical, physiological, serologic characteristics and outcomes of SINAM. The mean age of these patients was 66 ±9.4, the majority being male (61.3%). All patients reported proximal muscle weakness, and a few had myalgias, extra-muscular symptoms such as dysphagia, and pulmonary complications. Most of the patients were on atorvastatin, simvastatin, or rosuvastatin. The mean creatine kinase was 10,094.2 ±7,351.7 U/l, and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme was positive for 93.8% of patients. The majority of patients were started on steroids; other treatments were also used. Prompt cessation of statins and initiation of immunosuppressants reduced morbidity and mortality.
keywords:

atorvastatin, statins, statin-induced necrotizing autoimmune myopathy, muscle necrosis







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